Path of Agent

Viper Strike of the Mamba

Pathfinder


#24 most played skill on the Mirage ladder Built from 3.28 Mirage ladder data Generated 2026-04-20 Data via poe.ninja

Viper Strike of the Mamba Pathfinder is the patient assassin's build. You dash in, apply two or three poison stacks, dash out, and watch a lingering chaos damage over time pool melt the target while you already line up the next pack. Pathfinder's flask mastery is what holds it together — Master Surgeon refills charges on crit, and Nature's Adrenaline turns permanent flask uptime into permanent move speed and attack speed.

Consider this if you like layered, deliberate play — stacking Wither, Despair, and resist-reduction for multiplicative scaling, then watching bosses tick themselves to death. Not the right pick if you want raw hit damage or fast pack-clear on a budget; early mapping is the thinnest tier and the archetype only truly comes alive once Master Surgeon and a matched pair of can-poison daggers come online.

Is this build for me
Strengths
  • +Apex Pathfinder flask-sustain stack (Master Surgeon + The Tides of Time + Natural Remedies) — essentially permanent uptime on every utility flask
  • +Progenesis is the single strongest one-shot protection in the game — a quarter of every hit becomes a 4-second DoT the build easily out-regens
  • +Huge defensive ceiling via Divine Flesh + 81% chaos res — incoming elemental damage is absorbed by the chaos layer rather than stacking against specific caps
  • +Multiplicative boss-melt stack — Despair + Wither + Brood Visor's resist aura + weapon penetration pushes bosses to effectively -65% chaos resist before the DoT even ticks
  • +Evasion + suppression + ailment-avoidance stack with Ancestral Vision closes the ailment pillar cleanly
Weaknesses
  • Slow attack speed by design (~1.4 strikes/sec) — feel is "stack and walk away," not "swing fast"
  • Early mapping is the thinnest tier defensively — Tabula Rasa gives zero defence, so league-start play is careful
  • Needs specific chase uniques to come together — Progenesis, Brood Visor helm, and a matched can-poison dagger pair are not cheap
  • Poison-immune map mods and chaos-immune bosses (rare but they exist) are genuine walls — there's no hit-damage backup plan

Leveling L1–68


What to work on next
  1. Act 1: run Frost Blades
    Buy Frost Blades from Nessa after killing Hillock and use it on any white claw you find. Ancestral Call Support drops from the Brutus quest — it turns Frost Blades into a solid clear skill through the first acts. Pick up Whirling Blades as your travel skill from a claw vendor in Act 1. Slot a low-level Clarity once mana starts to feel tight. A Goldrim helmet and Wanderlust boots are cheap leveling uniques that cover resist and move speed needs.
  2. Act 2: run Frost Blades
    Pick up Herald of Agony from Yeena — this is the chaos-poison signature Herald of Agony and will carry through to endgame. Add Melee Physical Damage Support once you have a 4-link. Slot a low-level Cast when Damage Taken + Steelskin for panic defense. Take the "Alira" bandit reward (mana regen + crit multi + all res) — crit multi matters later and the resists smooth out gear requirements during leveling.
  3. Act 3: run Frost Blades
    Multistrike Support unlocks at L38 from Clarissa — slot it in for a major DPS jump. Grab Haste from the Library quest reward and run it alongside Clarity; the attack speed it provides is fantastic for a poison stacker. Pick up Flame Dash from the Library quest as a secondary mobility skill for gap-closing. Lab 1 here: Nature's Boon — this is where flasks start feeling free.
  4. Act 4: run Frost Blades
    Pick up Despair from the Act 4 vendor once you finish the Kaom storyline — this is the curse you'll run forever as a chaos-poison build. Self-cast for now; later you can auto-apply it. Keep running Frost Blades as the main skill — the transition to Viper Strike of the Mamba is one act away and you want to arrive with a clean 4-link ready to receive the new gem.
  5. Act 5–6: run Viper Strike of the Mamba
    Viper Strike of the Mamba is bought from Lilly Roth in Act 6 — this is the transition gem. Deadly Ailments Support and Vile Toxins Support are also from Lilly and are the two key poison support gems the build leans on. Keep Multistrike Support for the attack speed and extra hits (more poison stacks). A Bloodseeker claw fits perfectly here if you can get one — the innate leech is huge for survivability. Lab 2 in Act 6 area: Master Surgeon.
  6. Act 7+: run Viper Strike of the Mamba
    Slot Empower Support once you hit 5-link — it pushes Viper Strike of the Mamba's gem level for free chaos damage over time scaling. Run Precision at a low level for accuracy without eating too much mana; crit applies poison harder via Master Toxicist once you unlock it. Keep Haemophilia gloves on if you went that route — the increased poison damage from them is a significant chunk. Lab 3 in Act 9: Nature's Reprisal.
Skills by act
Act 1
Frost Blades Frost Blades Ancestral Call Support Ancestral Call Support
Travel Whirling Blades Whirling Blades
Auras Clarity Clarity

Buy Frost Blades from Nessa after killing Hillock and use it on any white claw you find. Ancestral Call Support drops from the Brutus quest — it turns Frost Blades into a solid clear skill through the first acts. Pick up Whirling Blades as your travel skill from a claw vendor in Act 1. Slot a low-level Clarity once mana starts to feel tight. A Goldrim helmet and Wanderlust boots are cheap leveling uniques that cover resist and move speed needs.

Act 2
Frost Blades Frost Blades Ancestral Call Support Ancestral Call Support Melee Physical Damage Support Melee Physical Damage Support
Travel Whirling Blades Whirling Blades
Auras Clarity Clarity
Heralds Herald of Agony Herald of Agony
Buffs Cast when Damage Taken Cast when Damage Taken Steelskin Steelskin

Pick up Herald of Agony from Yeena — this is the chaos-poison signature Herald of Agony and will carry through to endgame. Add Melee Physical Damage Support once you have a 4-link. Slot a low-level Cast when Damage Taken + Steelskin for panic defense. Take the "Alira" bandit reward (mana regen + crit multi + all res) — crit multi matters later and the resists smooth out gear requirements during leveling.

Act 3
Frost Blades Frost Blades Ancestral Call Support Ancestral Call Support Melee Physical Damage Support Melee Physical Damage Support Multistrike Support Multistrike Support
Travel Whirling Blades Whirling Blades
Auras Haste Haste Clarity Clarity
Heralds Herald of Agony Herald of Agony
Buffs Cast when Damage Taken Cast when Damage Taken Steelskin Steelskin

Multistrike Support unlocks at L38 from Clarissa — slot it in for a major DPS jump. Grab Haste from the Library quest reward and run it alongside Clarity; the attack speed it provides is fantastic for a poison stacker. Pick up Flame Dash from the Library quest as a secondary mobility skill for gap-closing. Lab 1 here: Nature's Boon — this is where flasks start feeling free.

Act 4
Frost Blades Frost Blades Ancestral Call Support Ancestral Call Support Melee Physical Damage Support Melee Physical Damage Support Multistrike Support Multistrike Support
Travel Whirling Blades Whirling Blades
Auras Haste Haste Clarity Clarity
Heralds Herald of Agony Herald of Agony
Buffs Cast when Damage Taken Cast when Damage Taken Steelskin Steelskin
Curse Despair Despair

Pick up Despair from the Act 4 vendor once you finish the Kaom storyline — this is the curse you'll run forever as a chaos-poison build. Self-cast for now; later you can auto-apply it. Keep running Frost Blades as the main skill — the transition to Viper Strike of the Mamba is one act away and you want to arrive with a clean 4-link ready to receive the new gem.

Act 5–6
Viper Strike of the Mamba Viper Strike of the Mamba Melee Physical Damage Support Melee Physical Damage Support Multistrike Support Multistrike Support Deadly Ailments Support Deadly Ailments Support Vile Toxins Support Vile Toxins Support
Travel Whirling Blades Whirling Blades
Auras Haste Haste Clarity Clarity
Heralds Herald of Agony Herald of Agony
Buffs Cast when Damage Taken Cast when Damage Taken Steelskin Steelskin
Curse Despair Despair

Viper Strike of the Mamba is bought from Lilly Roth in Act 6 — this is the transition gem. Deadly Ailments Support and Vile Toxins Support are also from Lilly and are the two key poison support gems the build leans on. Keep Multistrike Support for the attack speed and extra hits (more poison stacks). A Bloodseeker claw fits perfectly here if you can get one — the innate leech is huge for survivability. Lab 2 in Act 6 area: Master Surgeon.

Act 7+
Viper Strike of the Mamba Viper Strike of the Mamba Melee Physical Damage Support Melee Physical Damage Support Multistrike Support Multistrike Support Deadly Ailments Support Deadly Ailments Support Vile Toxins Support Vile Toxins Support Empower Support Empower Support
Travel Whirling Blades Whirling Blades
Auras Haste Haste Precision Precision Clarity Clarity
Heralds Herald of Agony Herald of Agony
Buffs Cast when Damage Taken Cast when Damage Taken Steelskin Steelskin
Curse Despair Despair

Slot Empower Support once you hit 5-link — it pushes Viper Strike of the Mamba's gem level for free chaos damage over time scaling. Run Precision at a low level for accuracy without eating too much mana; crit applies poison harder via Master Toxicist once you unlock it. Keep Haemophilia gloves on if you went that route — the increased poison damage from them is a significant chunk. Lab 3 in Act 9: Nature's Reprisal.

Maps L68+
Viper Strike of the Mamba Viper Strike of the Mamba Melee Physical Damage Support Melee Physical Damage Support Multistrike Support Multistrike Support Deadly Ailments Support Deadly Ailments Support Vile Toxins Support Vile Toxins Support Empower Support Empower Support
Travel Whirling Blades Whirling Blades
Auras Haste Haste Precision Precision Clarity Clarity
Heralds Herald of Agony Herald of Agony
Buffs Cast when Damage Taken Cast when Damage Taken Steelskin Steelskin
Curse Despair Despair

Run Uber Lab as soon as you hit L68 to grab Master Toxicist — this is the single biggest damage spike for the build and is when the early-mapping tier of the guide picks up. Until you have it, your poison damage will feel flat; after you take it, the build clicks into the chaos damage over time monster it's known for. Aim to cap elemental resists at 75% resist before pushing red maps, and look for a real endgame claw with flat chaos damage and attack speed.

How leveling works

Viper Strike of the Mamba is a transfigured claw/dagger attack that stacks heavy poison on every hit, scaling almost entirely through chaos damage over time rather than hit damage. As a Pathfinder you lean on Master Surgeon for permanent flask uptime, Nature's Reprisal for bonus chaos damage over time while flasks are active, and Master Toxicist for the signature poison multiplier. The build doesn't truly come online until you have the transfigured gem (purchased from Lilly Roth in Act 6) plus a 4-link that can host Deadly Ailments Support and Vile Toxins Support, so the early campaign is spent on a placeholder skill.

The recommended path is Frost Blades on a claw for Acts 1–4 (keeps you on-weapon and on-archetype), then swap to Viper Strike of the Mamba in Act 5–6 once Lilly Roth is available. The Pathfinder ascendancy points you'll grab in the Labs are: Nature's BoonMaster SurgeonNature's ReprisalMaster Toxicist. Master Surgeon is the build-defining pickup: permanent flask uptime keeps Nature's Reprisal's damage bonus live at all times, which is how the build gets its mapping smoothness.

Rare jewellery with life and resists, a 5-link as soon as you can craft one, and a Tabula Rasa if you find one will carry you through the campaign. Bloodseeker is a strong leveling claw once you hit its level requirement; Haemophilia gloves give free poison scaling. Save currency for the endgame transition — don't sink it into leveling uniques beyond those two.

Gear while leveling
  • · Weapon: a claw while leveling — Bloodseeker is ideal once you hit its level requirement for the innate leech. Before that, any rare claw with flat physical or chaos damage and attack speed. Vendor-recipe elemental claws (magic claw + topaz/sapphire/ruby + Blacksmith's Whetstone) are fine stopgaps through early acts.
  • · Body armour: rush a Tabula Rasa if you can find/buy one — a guaranteed 6-link is worth more than any leveling rare. Otherwise a 4-link evasion chest with life and resists.
  • · Gloves: Haemophilia is a cheap, permanent-until-endgame pickup — the increased poison damage is a core scaler for the whole build.
  • · Helmet/boots: prioritise life and resists. Goldrim and Wanderlust as cheap early-act slot fillers; swap to rares once you need the life.
  • · Rings/amulet: life + resists, with attribute fix-ups as needed. A cheap rare amulet with chaos damage over time multiplier once available is a major spike.
  • · Belt: Heavy Belt or Leather Belt with life and resists. No unique belts needed during leveling.
  • · Flasks: this is where Pathfinder shines — a life flask with bleed-removal, a quicksilver, a granite, a silver or sulphur for offence, and a diamond flask once available. All five benefit from flask effect and flask uptime via Master Surgeon.
Weapon progression

Any rare 1H claw with flat physical damage and attack speed carries the early acts. Al Dhih is a cheap claw option in mid-acts if you find one. The build-defining leveling claw is Bloodseeker — pick it up as soon as you hit the level requirement for the innate leech, which massively smooths out survivability during the Viper Strike of the Mamba transition. The endgame target weapon is a rare Imperial Claw or similar with flat chaos damage, attack speed, and crit — but that is far above leveling priorities. Get to maps with any decent claw, then start hunting the upgrade.

Tree to aim for (by level 90)
Claws of the Magpie Profane Chemistry Arena Challenger Master Toxicist Nature's Reprisal
Open the full leveling tree
Watch out for
  • ! Don't take Vile Toxins Support before you have the transfigured gem — on a placeholder like Frost Blades it doesn't help much because you aren't stacking enough poison yet. Vile Toxins Support scales WITH poison stacks, so it wants the real skill to be online first.
  • ! Master Surgeon gives permanent flask uptime only while you're generating flask charges — make sure at least one utility flask has the "enchanted" or innate charge-on-crit behaviour or you can run dry in long boss fights. Pathfinder auto-refills via Nature's Boon partly mitigates this but don't rely on it 100%.
  • ! Herald of Agony's Virulence stacks come from applying poison, not from hitting. Early on with Frost Blades you won't be poisoning reliably — the herald minion will feel weak until Viper Strike of the Mamba takes over. Don't panic and swap it out.
  • ! Chaos Inoculation is NOT taken on this build — Pathfinder wants life + flask-based defences, not ES. Ignore any guide that mentions Chaos Inoculation for a Viper Strike variant; that's a different archetype.
  • ! Cospri's Malice is sometimes suggested as a leveling claw, but it's a cold-damage weapon and fights against the chaos scaling — skip it and use Bloodseeker or a rare claw instead.

Early Mapping L70–84


What to work on next
  1. Replace Tabula Rasa with a 6-link The Covenant or rare evasion chest once the build can afford the jeweller/fusing cost — instantly adds 1k+ life and starts closing the suppress gap
  2. Swap the Pressurised Dagger for a rare Pneumatic Dagger with "All Damage from Hits with This Weapon can Poison" + +Chaos Damage over Time Multiplier — the Pneumatic base has higher crit and implicit poison scaling
  3. Pick up Master Surgeon as the fourth ascendancy next — instant flask charges on crit turn flask uptime from 'mostly on' to 'permanently on'
Signature items
The Tides of Time
The Tides of Time
Vanguard Belt
The Sorrow of the Divine
The Sorrow of the Divine
Sulphur Flask
Taste of Hate
Taste of Hate
Sapphire Flask
Voices
Voices
Large Cluster Jewel
Megalomaniac
Megalomaniac
Medium Cluster Jewel
Main link
Viper Strike of the MambaViper Strike of the Mamba
+Swift AfflictionSwift Affliction
+Added Chaos DamageAdded Chaos Damage
+Deadly AilmentsDeadly Ailments
+Melee Physical DamageMelee Physical Damage
+FortifyFortify
DPS
4.51M
EHP
20.3k
Life
3.1k
ES
1.1k

Stats measured in Path of Building at level 84, from the ladder data this guide is built on. Ladder median (n=47): 431.0k DPS · 16.3k EHP.

Full stats
Fire res
75%
Cold res
83%
Lightning res
75%
Chaos res
21%
Block
20%
Spell block
0%
Spell suppression
54%
Phys reduction
4%
Life regen
1.7k/s
Crit chance
50.1%
Crit multi
288%
Speed
1.43/s
Str / Dex / Int
239 / 249 / 192
Full gear (26 items)
Hypnotic Barb Hypnotic Barb Weapon 1
Hypnotic Barb
Hypnotic Barb Weapon 1
Pneumatic Dagger

  • All Damage from Hits with This Weapon can Poison

  • +36 to Intelligence
  • +28% to Chaos Damage over Time Multiplier
  • Adds 90 to 168 Cold Damage
  • Adds 9 to 169 Lightning Damage
  • 11% increased Stun Duration on Enemies
  • Hits can't be Evaded (crafted)
Torment Etcher Torment Etcher Weapon 2
Torment Etcher
Torment Etcher Weapon 2
Pneumatic Dagger

  • All Damage from Hits with This Weapon can Poison

  • Adds 9 to 167 Lightning Damage
  • +35% to Chaos Damage over Time Multiplier
  • Adds 95 to 186 Cold Damage
  • 26% increased Attack Speed
  • 28% increased Critical Strike Chance
  • Hits can't be Evaded (crafted)
Havoc Cowl Havoc Cowl Helmet
Havoc Cowl
Havoc Cowl Helmet
Blizzard Crown

  • Adds 76 to 128 Cold Damage
  • Your Hits treat Cold Resistance as 10% higher than actual value

  • +128 to maximum Life
  • Regenerate 12.9 Life per second
  • +44% to Fire Resistance
  • +33% to Chaos Resistance
  • Reflects 7 Physical Damage to Melee Attackers
  • 20% increased Evasion and Energy Shield (crafted)
  • +15 to maximum Life (crafted)
Dusk Salvation Dusk Salvation Body Armour
Dusk Salvation
Dusk Salvation corrupted Body Armour
Torturer Garb

  • 57% increased Evasion and Energy Shield
  • 41% faster start of Energy Shield Recharge
  • +151 to maximum Life
  • Regenerate 57.7 Life per second
  • +45 to maximum Mana
  • +40% to Lightning Resistance
Morbid Touch Morbid Touch Gloves
Morbid Touch
Morbid Touch Gloves
Hydrascale Gauntlets

  • Adds 2 to 23 Lightning Damage to Attacks

  • Adds 15 to 25 Fire Damage to Attacks
  • +44% to Cold Resistance
  • +44% to Lightning Resistance
  • Gain 21 Mana per Enemy Killed
Brimstone Tread Brimstone Tread Boots
Brimstone Tread
Brimstone Tread Boots
Harpyskin Boots

  • Gain 4% of Physical Damage as Extra Cold Damage

  • +34% to Lightning Resistance
  • +99 to Evasion Rating
  • +117 to maximum Life
  • +41% to Fire Resistance
  • +45% to Cold Resistance
  • 18% increased Movement Speed (crafted)
  • 100% chance to Avoid being Chilled (crafted)
Entropy Collar Entropy Collar Amulet
Entropy Collar
Entropy Collar Amulet
Jade Amulet

  • Allocates Sione's Ambition
  • +30 to Dexterity

  • +124 to Strength
  • +55% to Damage over Time Multiplier
  • Adds 34 to 59 Fire Damage to Attacks
  • Adds 9 to 16 Cold Damage to Attacks against you
  • -80 to maximum Life
  • -27% to Lightning Resistance
Blood Twirl Blood Twirl Ring 1
Blood Twirl
Blood Twirl Ring 1
Two-Stone Ring

  • +14% to Fire and Cold Resistances

  • Adds 2 to 5 Physical Damage to Attacks
  • Adds 4 to 8 Cold Damage to Attacks
  • 16% increased Rarity of Items found
  • +35% to Fire Resistance
  • +11% to Lightning Resistance
Behemoth Twirl Behemoth Twirl Ring 2
Behemoth Twirl
Behemoth Twirl Ring 2
Topaz Ring

  • +25% to Lightning Resistance

  • +44% to Cold Resistance
  • +42 to Intelligence
  • Adds 10 to 19 Fire Damage to Attacks
  • +44 to maximum Mana
  • +35% to Chaos Resistance
  • Non-Channelling Skills have -8 to Total Mana Cost (crafted)
The Tides of Time The Tides of Time Belt
The Tides of Time
The Tides of Time corrupted Belt
Vanguard Belt

  • +315 to Armour and Evasion Rating

  • 146% increased Life Recovery from Flasks
  • 136% increased Mana Recovery from Flasks
  • Flasks applied to you have 21% increased Effect
  • Life Flasks gain 3 Charges every 3 seconds
  • Mana Flasks gain 1 Charge every 3 seconds
  • Utility Flasks gain 1 Charge every 3 seconds
Fulgent Prism Fulgent Prism Jewel
Fulgent Prism
Fulgent Prism Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +3% to Chaos Resistance
  • Added Small Passive Skills also grant: 2% increased Damage over Time
  • 1 Added Passive Skill is Exposure Therapy
  • 1 Added Passive Skill is Low Tolerance
Whispering Gaze Whispering Gaze Jewel
Whispering Gaze
Whispering Gaze Tree Jewel
Murderous Eye Jewel

  • Adds 14 to 28 Fire Damage to Attacks
  • Adds 2 to 25 Lightning Damage to Attacks
  • 14 to 23 Added Fire Damage with Dagger Attacks
  • 13 to 24 Added Cold Damage with Dagger Attacks
Hollow Gaze Hollow Gaze Jewel
Hollow Gaze
Hollow Gaze Tree Jewel
Murderous Eye Jewel

  • Adds 12 to 23 Cold Damage to Attacks
  • Adds 4 to 44 Lightning Damage to Attacks
  • 8 to 15 Added Fire Damage with Dagger Attacks
  • 1 to 19 Added Lightning Damage with Dagger Attacks
Spirit Song Spirit Song Jewel
Spirit Song
Spirit Song Tree Jewel
Viridian Jewel

  • +6% to Chaos Damage over Time Multiplier
  • 14% increased Damage with Daggers
  • 13% increased Chaos Damage
  • Attacks have 5% chance to cause Bleeding
  • 12% increased Bleeding Duration
Voices Voices Jewel
Voices
Voices corrupted Tree Jewel
Large Cluster Jewel

  • Adds 3 Jewel Socket Passive Skills
  • Adds 5 Small Passive Skills which grant nothing
Megalomaniac Megalomaniac Jewel
Megalomaniac
Megalomaniac corrupted Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • Added Small Passive Skills grant Nothing
  • 1 Added Passive Skill is Low Tolerance
  • 1 Added Passive Skill is Pure Might
  • 1 Added Passive Skill is Touch of Cruelty
Grim Bite Grim Bite Jewel
Grim Bite
Grim Bite Tree Jewel
Murderous Eye Jewel

  • Adds 12 to 24 Fire Damage to Attacks
  • Adds 2 to 48 Lightning Damage to Attacks
  • 12 to 22 Added Cold Damage with Dagger Attacks
  • 4 to 35 Added Lightning Damage with Dagger Attacks
Glorious Vanity Glorious Vanity Jewel
Glorious Vanity
Glorious Vanity Tree Jewel
Timeless Jewel

  • Bathed in the blood of 1782 sacrificed in the name of Doryani
  • Passives in radius are Conquered by the Vaal
  • Historic
Armageddon Stone Armageddon Stone Jewel
Armageddon Stone
Armageddon Stone Tree Jewel
Medium Cluster Jewel

  • Adds 5 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: Regenerate 0.1% of Life per Second
  • Added Small Passive Skills also grant: +4 to Strength
  • 1 Added Passive Skill is Exposure Therapy
  • 1 Added Passive Skill is Low Tolerance
Sol Star Sol Star Jewel
Sol Star
Sol Star Tree Jewel
Viridian Jewel

  • +8 to Strength and Dexterity
  • 10% increased Melee Damage
  • 6% increased maximum Life
  • Damaging Ailments deal damage 4% faster
Glyph Sliver Glyph Sliver Jewel
Glyph Sliver
Glyph Sliver Tree Jewel
Crimson Jewel

  • +9 to Strength and Dexterity
  • 10% increased Damage over Time
  • 13% increased Damage with One Handed Weapons
  • Damaging Ailments deal damage 6% faster
Divine Life Flask
Divine Life Flask Flask 1

  • 42% increased Amount Recovered
  • 33% reduced Recovery rate
  • Grants Immunity to Bleeding for 6 seconds if used while Bleeding
  • Grants Immunity to Corrupted Blood for 6 seconds if used while affected by Corrupted Blood
The Sorrow of the Divine
The Sorrow of the Divine Flask 2
Sulphur Flask

  • Life Recovery from Flasks also applies to Energy Shield during Effect
  • 40% increased Duration
  • Zealot's Oath during Effect
Taste of Hate
Taste of Hate Flask 3
Sapphire Flask

  • 23% of Fire and Lightning Damage from Hits taken as Cold Damage during Effect
  • Gain 12% of Physical Damage as Extra Cold Damage during effect
  • 30% chance to Avoid being Chilled during Effect
  • 30% chance to Avoid being Frozen during Effect
Jade Flask
Jade Flask Flask 4

  • 24% increased Charge Recovery
  • 26% increased Critical Strike Chance during Effect
Quicksilver Flask
Quicksilver Flask Flask 5

  • 11% chance to gain a Flask Charge when you deal a Critical Strike
  • 8% increased Movement Speed during Effect
All gem links (6 groups)
Gloves 4-link
  • Despair Despair 20/17
  • Alchemist's Mark Alchemist's Mark L20
  • Autoexertion Autoexertion L15
  • Battlemage's Cry Battlemage's Cry L20
Boots 3-link
  • Malevolence Malevolence L20
  • Petrified Blood Petrified Blood L16
  • Flesh and Stone Flesh and Stone L5
Helmet 4-link
  • Blood Rage Blood Rage L20
  • Autoexertion Autoexertion L15
  • Ambush Ambush L20
  • Ancestral Cry Ancestral Cry L15
Weapon 1 3-link
  • Flame Dash Flame Dash L6
  • Withering Step Withering Step L20
  • Enhance Enhance L2
Weapon 2 3-link
  • Purity of Elements Purity of Elements L4
  • Whirling Blades Whirling Blades L20
  • Faster Attacks Faster Attacks L20
Body Armour 6-link Main link
  • Swift Affliction Swift Affliction 20/20
  • Added Chaos Damage Added Chaos Damage 20/20
  • Deadly Ailments Deadly Ailments L21
  • Viper Strike of the Mamba Viper Strike of the Mamba 19/20
  • Melee Physical Damage Melee Physical Damage L20
  • Fortify Fortify L20
How this stage plays (mechanics, defences)
Mechanics

At this tier Viper Strike of the Mamba is already running its signature engine — a transfigured dagger strike that stacks chaos poison and lingers as a chaos damage over time pool that follows the enemy. The reference L78 Pathfinder mains a rare Pressurised Dagger (Death Razor) with the critical "All Damage from Hits with This Weapon can Poison" suffix, paired with a Bino's Kitchen Knife in the second hand — the Slaughter Knife's on-kill poison-proliferation radius is doing most of the early map clearing. The 6-link lives in a Tabula Rasa: Viper Strike of the Mamba + Added Chaos Damage + Void Manipulation + Swift Affliction + Deadly Ailments + Efficacy, a pure ailment-scaling stack that leans into poison DoT rather than hit damage. Ashes of the Stars amulet adds +1 to Level of all Skill Gems plus +25% quality, so every linked support is overlevelled and overqualitied for the tier.

A Spell Totem + Multiple Totems setup fires Wither stacks on bosses (up to 15% increased chaos damage taken per stack), and Despair curses the target via Alchemist's Mark mark-on-hit from the boots. Malevolence + Grace reserve mana for chaos damage over time multiplier and evasion scaling, and Herald of Agony rides the build's guaranteed poison application for a permanent Agony Crawler minion. Tree points fund Master Toxicist, Toxic Strikes, Fatal Toxins, Swift Venoms, and Wasting — the classic poison notable rosary — plus Herbalism and Careful Conservationist for flask charge income that Pathfinder lives on. Sheet 1.34M DPS reads above the tier median of 431k because Wither, poison stacks, and Despair are already layered.

Defensive layers

Defence is the thin-but-functional early-map stack: 4,059 life, 22k evasion, 63% spell suppress (not yet capped), and 53% chaos resist from ring/jewel rolls. EHP 17.6k sits on top of the tier median. The Tabula Rasa costs all body-armour defence — no life, no evasion, no resists from the chest slot — which is the single biggest reason EHP isn't higher. Elemental resistances cap cleanly with comfortable overcap (+10/+17/+22% fire/cold/lightning), protecting against shock/chill application. Thick Skin and Blood Drinker give baseline life + leech, and the Stibnite Flask's 49% reduced Chill effect + 52% reduced Freeze duration line plugs the ailment gap while suppress is still incomplete. Flask uptime is already the Pathfinder identity — flask effect duration rolls on Glyph Vessel jewel + Pandemonium Bliss + tree nodes keep Jade, Quicksilver, and the Stibnite rolling almost continuously.

What it feels like

Slow-building but forgiving. Viper Strike of the Mamba itself isn't fast (1.41 attacks/sec sheet speed), but poison stacks compound on bosses while Bino's Kitchen Knife's on-kill proliferation wipes packs around corpses. Flame Dash in the claw carries movement, and the Brewer's Jade + Brewer's Quicksilver combo gives permanent evasion + move speed during sustained combat. Single target is the build's strength at this tier: apply Wither via totem, mark with Alchemist's Mark to auto-Despair, strike once or twice, walk away while the poison ticks kill. Clear is slower than a typical hit-based build but never dangerous — the Agony Crawler from Herald of Agony is already tanky enough to hold aggro on rares while you reposition.

Passive tree (122 points)
Keystones
Corrupted Soul (transformed from Elemental Equilibrium)
Ascendancy
Master Toxicist Nature's Reprisal Nature's Adrenaline Master Surgeon
Notables
Master ToxicistCharismaSwift VenomsInfluenceThrill of BattleWritten in BloodHerbalismWhispers of DoomPrimal SpiritBlood DrinkerFatal ToxinsCareful ConservationistSoul ThiefNature's ReprisalNatural Remedies

The desktop app shows this tier's full tree on an interactive canvas.

Endgame L85–94


What to work on next
  1. The main transitions at endgame are the body armour swap, a keystone pivot, and the weapon pair upgrade. Tabula Rasa is replaced by Doppelganger Guise (the Sadist Garb unique), Bino's Kitchen Knife is dropped for a matched pair of rare Pneumatic Daggers both carrying the "All Damage from Hits with This Weapon can Poison" suffix, and a Glorious Vanity timeless jewel in the Vaal cluster rewrites Elemental Equilibrium into Divine Flesh — turning 50% of elemental damage taken into chaos, which the build's 83% chaos resist absorbs cheaply. Master Surgeon is picked up as the fourth ascendancy.
  2. Upgrade Swift Affliction and Deadly Ailments to Lv21 via 20% quality gem corruption — ~10% more DoT multiplier on a sixth of the build's damage
  3. Replace the Brewer's Quicksilver with a Progenesis Amethyst Flask — 25% of hit damage taken over 4s is the single strongest one-shot protection a Pathfinder can slot
  4. Swap to Mageblood once budget allows — guaranteed four-flask uptime scales every utility flask's damage/defence line at once
Signature items
Bino's Kitchen Knife
Bino's Kitchen Knife
Slaughter Knife
Maloney's Mechanism
Maloney's Mechanism
Ornate Quiver
Whispers of Infinity
Whispers of Infinity
Seaglass Amulet
Shavronne's Revelation
Shavronne's Revelation
Moonstone Ring
The Tides of Time
The Tides of Time
Vanguard Belt
Main link
Viper Strike of the MambaViper Strike of the Mamba
+Deadly AilmentsDeadly Ailments
+CrueltyCruelty
+Melee Physical DamageMelee Physical Damage
+Swift AfflictionSwift Affliction
+Added Chaos DamageAdded Chaos Damage
+Cast on Melee KillCast on Melee Kill
DPS
4.80M
EHP
34.1k
Life
1
ES
6.7k

Stats measured in Path of Building at level 92, from the ladder data this guide is built on. Ladder median (n=151): 6.10M DPS · 42.1k EHP.

Full stats
Fire res
75%
Cold res
75%
Lightning res
76%
Chaos res
-4%
Block
20%
Spell block
0%
Spell suppression
81%
Phys reduction
3%
Life regen
0/s
Crit chance
24.2%
Crit multi
195%
Speed
1.84/s
Str / Dex / Int
142 / 266 / 323
Full gear (31 items)
Eagle Spiker Eagle Spiker Weapon 1
Eagle Spiker
Eagle Spiker Weapon 1
Imperial Skean

  • 30% increased Global Critical Strike Chance

  • +24% to Damage over Time Multiplier
  • +22% to Chaos Damage over Time Multiplier
  • Adds 73 to 155 Chaos Damage
  • 37% increased Critical Strike Chance
  • +135 to maximum Mana
  • Hits can't be Evaded (crafted)
Bino's Kitchen Knife Bino's Kitchen Knife Weapon 2
Bino's Kitchen Knife
Bino's Kitchen Knife Weapon 2
Slaughter Knife

  • 30% increased Global Critical Strike Chance

  • Adds 152 to 225 Physical Damage
  • 41% increased Critical Strike Chance
  • +24% to Global Critical Strike Multiplier
  • +26% to Chaos Resistance
  • On Killing a Poisoned Enemy, Enemies within 3 metres are Poisoned, and you and
  • Allies Regenerate 400 Life per second for the Poison's duration if within 3 metres
Dusk Strike Dusk Strike Weapon 1 Swap
Dusk Strike
Dusk Strike Weapon 1 Swap
Spine Bow

  • 18% reduced Attribute Requirements
  • Adds 44 to 81 Physical Damage
  • Adds 225 to 388 Fire Damage
  • Adds 32 to 628 Lightning Damage
  • +37% to Global Critical Strike Multiplier
  • 45% increased Projectile Speed
Maloney's Mechanism Maloney's Mechanism Weapon 2 Swap
Maloney's Mechanism
Maloney's Mechanism Weapon 2 Swap
Ornate Quiver

  • Has 1 Socket

  • Has 2 Sockets
  • Trigger a Socketed Bow Skill when you Attack with a Bow, with a 1 second Cooldown
  • 10% increased Attack Speed
  • +53 to maximum Life
  • 5% chance to Blind Enemies on Hit with Attacks
Dire Shelter Dire Shelter Helmet
Dire Shelter
Dire Shelter Helmet
Lich's Circlet

  • 6% of Physical Damage from Hits taken as Chaos Damage
  • +1% to maximum Lightning Resistance

  • +55 to maximum Energy Shield
  • 29% increased Energy Shield
  • 31% increased Energy Shield Recharge Rate
  • +30% to Fire Resistance
  • +8% to Cold Resistance
  • 12% increased Stun and Block Recovery
  • 71% increased Energy Shield (crafted)
Havoc Hide Havoc Hide Body Armour
Havoc Hide
Havoc Hide Body Armour
Twilight Regalia

  • 11% of Physical Damage from Hits taken as Chaos Damage
  • +21% to Critical Strike Multiplier for Attack Damage

  • 100% increased Energy Shield
  • +43 to Intelligence
  • +92 to maximum Energy Shield
  • 40% increased Energy Shield
  • +47% to Cold Resistance
  • 17% increased Stun and Block Recovery
  • +25 to Strength and Dexterity (crafted)
Hypnotic Knuckle Hypnotic Knuckle Gloves
Hypnotic Knuckle
Hypnotic Knuckle Gloves
Warlock Gloves

  • 13% increased Attack Speed
  • +46 to maximum Energy Shield
  • 85% increased Energy Shield
  • +48% to Cold Resistance
  • +34% to Lightning Resistance
  • 19% increased Energy Shield (crafted)
  • +14 to maximum Life (crafted)
Dread Urge Dread Urge Boots
Dread Urge
Dread Urge Boots
Warlock Boots

  • Gain 4% of Physical Damage as Extra Chaos Damage
  • 4% increased Action Speed

  • 95% increased Energy Shield
  • +58 to Intelligence
  • +42 to maximum Energy Shield
  • 36% increased Energy Shield Recharge Rate
  • +44% to Lightning Resistance
  • 20% increased Movement Speed (crafted)
  • 100% chance to Avoid being Chilled (crafted)
Whispers of Infinity Whispers of Infinity Amulet
Whispers of Infinity
Whispers of Infinity corrupted Amulet
Seaglass Amulet

  • Allocates Sione's Ambition
  • 14% faster start of Energy Shield Recharge

  • 12 to 32 Added Attack Chaos Damage per 100 Maximum Mana
  • +73 to maximum Energy Shield
  • 64% reduced maximum Mana
  • Skills Cost Energy Shield instead of Mana or Life
Phoenix Hold Phoenix Hold Ring 1
Phoenix Hold
Phoenix Hold Ring 1
Moonstone Ring

  • +22 to maximum Energy Shield

  • Adds 15 to 21 Fire Damage
  • Adds 15 to 20 Lightning Damage
  • +70 to maximum Mana
  • +15% to all Elemental Resistances
  • +38% to Fire Resistance
  • +42% to Lightning Resistance
  • +53 to maximum Life (crafted)
Shavronne's Revelation Shavronne's Revelation Ring 2
Shavronne's Revelation
Shavronne's Revelation Ring 2
Moonstone Ring

  • +30 to maximum Energy Shield

  • +62 to Intelligence
  • Right ring slot: You cannot Regenerate Mana
  • Right ring slot: Regenerate 7.2% of Energy Shield per second
  • Right ring slot: +250 to maximum Mana
  • Left ring slot: You cannot Recharge or Regenerate Energy Shield
  • Left ring slot: Regenerate 40 Mana per Second
  • Left ring slot: +300 to maximum Energy Shield
The Tides of Time The Tides of Time Belt
The Tides of Time
The Tides of Time Belt
Vanguard Belt

  • +304 to Armour and Evasion Rating

  • 100% increased Life Recovery from Flasks
  • 100% increased Mana Recovery from Flasks
  • Flasks applied to you have 25% increased Effect
  • Life Flasks gain 1 Charge every 3 seconds
  • Utility Flasks gain 3 Charges every 3 seconds
Hypnotic Glimmer Hypnotic Glimmer Jewel
Hypnotic Glimmer
Hypnotic Glimmer Tree Jewel
Medium Cluster Jewel

  • Adds 5 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: 2% increased Damage over Time
  • Added Small Passive Skills also grant: +3 to Dexterity
  • 1 Added Passive Skill is Eldritch Inspiration
  • 1 Added Passive Skill is Low Tolerance
Dragon Stone Dragon Stone Jewel
Dragon Stone
Dragon Stone Tree Jewel
Cobalt Jewel

  • +15 to Strength
  • +8% to Chaos Damage over Time Multiplier
  • 7% increased maximum Energy Shield
  • 8% increased Flask Effect Duration
Phoenix Curio Phoenix Curio Jewel
Phoenix Curio
Phoenix Curio Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: 1% increased Damage over Time
  • Added Small Passive Skills also grant: 2% increased Damage
  • Added Small Passive Skills also grant: +2% to Lightning Resistance
  • 1 Added Passive Skill is Eldritch Inspiration
Brood Eye Brood Eye Jewel
Brood Eye
Brood Eye Tree Jewel
Cobalt Jewel

  • +7% to Chaos Damage over Time Multiplier
  • 7% increased maximum Energy Shield
  • +14% to Fire Resistance
Rapture Glisten Rapture Glisten Jewel
Rapture Glisten
Rapture Glisten Tree Jewel
Large Cluster Jewel

  • Adds 8 Passive Skills
  • 2 Added Passive Skills are Jewel Sockets
  • Added Small Passive Skills grant: 12% increased Chaos Damage

  • 1 Added Passive Skill is Unwaveringly Evil
  • Added Small Passive Skills also grant: +2 to Intelligence
  • Added Small Passive Skills also grant: Regenerate 0.1% of Life per Second
  • 1 Added Passive Skill is Touch of Cruelty
Rapture Hope Rapture Hope Jewel
Rapture Hope
Rapture Hope Tree Jewel
Cobalt Jewel

  • +16 to Strength
  • 6% increased maximum Energy Shield
  • Damaging Ailments deal damage 6% faster
  • 34% reduced Poison Duration on you
Voices Voices Jewel
Voices
Voices corrupted Tree Jewel
Large Cluster Jewel

  • Adds 3 Jewel Socket Passive Skills
  • Adds 5 Small Passive Skills which grant nothing
Damnation Wound Damnation Wound Jewel
Damnation Wound
Damnation Wound Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +2 to All Attributes
  • Added Small Passive Skills also grant: +2% to Lightning Resistance
  • 1 Added Passive Skill is Eldritch Inspiration
  • 1 Added Passive Skill is Low Tolerance
Brutal Restraint Brutal Restraint Jewel
Brutal Restraint
Brutal Restraint Tree Jewel
Timeless Jewel

  • Denoted service of 6574 dekhara in the akhara of Nasima
  • Passives in radius are Conquered by the Maraketh
  • Historic
Foe Ruin Foe Ruin Jewel
Foe Ruin
Foe Ruin Tree Jewel
Medium Cluster Jewel

  • Adds 5 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • 1 Added Passive Skill is Low Tolerance
  • Added Small Passive Skills also grant: +3% to Chaos Resistance
  • Added Small Passive Skills also grant: +3% to Fire Resistance
  • 1 Added Passive Skill is Eldritch Inspiration
Eagle Ornament Eagle Ornament Jewel
Eagle Ornament
Eagle Ornament Tree Jewel
Cobalt Jewel

  • +8% to Chaos Damage over Time Multiplier
  • 6% increased maximum Energy Shield
  • 4% increased Attack and Cast Speed
  • 7% increased Flask Effect Duration
Ghoul Creed Ghoul Creed Jewel
Ghoul Creed
Ghoul Creed corrupted Tree Jewel
Cobalt Jewel

  • 20% reduced Poison Duration on you

  • +7% to Chaos Damage over Time Multiplier
  • 7% increased maximum Energy Shield
  • +13% to Fire Resistance
Watcher's Eye Watcher's Eye Jewel
Watcher's Eye
Watcher's Eye Tree Jewel
Prismatic Jewel

  • 6% increased maximum Energy Shield
  • 6% increased maximum Life
  • 5% increased maximum Mana
  • +22% to Damage over Time Multiplier while affected by Malevolence
  • Gain 10% of Maximum Mana as Extra Maximum Energy Shield while affected by Clarity
  • +12% chance to Suppress Spell Damage while affected by Grace
Rapture Desire Rapture Desire Jewel
Rapture Desire
Rapture Desire Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +3% to Cold Resistance
  • Added Small Passive Skills also grant: +5% to Fire Resistance
  • Added Small Passive Skills have 25% increased Effect
  • 1 Added Passive Skill is Eldritch Inspiration
The Sorrow of the Divine
The Sorrow of the Divine Flask 1
Sulphur Flask

  • Life Recovery from Flasks also applies to Energy Shield during Effect
  • 50% increased Duration
  • Zealot's Oath during Effect
Silver Flask
Silver Flask Flask 2

  • 50% increased Charge Recovery
  • 58% reduced Effect of Curses on you during Effect
Stibnite Flask
Stibnite Flask Flask 3

  • 54% increased Charge Recovery
  • 25% reduced effect
  • 14% increased Movement Speed during Effect
Jade Flask
Jade Flask Flask 4

  • 61% increased Charge Recovery
  • 25% reduced effect
  • 60% increased Evasion Rating during Effect
Quicksilver Flask
Quicksilver Flask Flask 5

  • 44% increased Charge Recovery
  • 25% reduced effect
  • 16% additional Elemental Resistances during Effect
All gem links (13 groups)
Gloves 2-link
  • Spell Totem Spell Totem L21
  • Wither Wither L21
Gloves 2-link
  • Frostblink Frostblink L21
  • Precision Precision L21
Weapon 2
  • Despair Despair 20/20
Weapon 2 2-link
  • Alchemist's Mark Alchemist's Mark 20/20
  • Mark On Hit Mark On Hit 20/20
Weapon 2 Swap
  • Flicker Strike Flicker Strike L18
Weapon 2 Swap
  • Flicker Strike Flicker Strike L18
Weapon 2 Swap
  • Flicker Strike Flicker Strike L18
Weapon 1 3-link
  • Whirling Blades Whirling Blades L21
  • Momentum Momentum L21
  • Faster Attacks Faster Attacks L21
Helmet 4-link
  • Discipline Discipline L21
  • Malevolence Malevolence L21
  • Enlighten Enlighten L2
  • Vaal Grace Vaal Grace L20
Body Armour 7-link Main link
  • Viper Strike of the Mamba Viper Strike of the Mamba 20/20
  • Deadly Ailments Deadly Ailments L21
  • Cruelty Cruelty L21
  • Melee Physical Damage Melee Physical Damage L21
  • Swift Affliction Swift Affliction L21
  • Added Chaos Damage Added Chaos Damage L21
  • Cast on Melee Kill Cast on Melee Kill L1
Boots
  • Automation Automation 20/20
Boots
  • Clarity Clarity 20/20
Weapon 1 Swap 6-link
  • Increased Critical Damage Increased Critical Damage L18
  • Increased Critical Damage Increased Critical Damage L18
  • Increased Critical Damage Increased Critical Damage L18
  • Increased Critical Damage Increased Critical Damage L18
  • Increased Critical Damage Increased Critical Damage L18
  • Flicker Strike Flicker Strike L18
How this stage plays (mechanics, defences)
Mechanics

The rare dagger pair is the damage story. Torment Sever (main hand) adds +21% chaos damage over time multiplier, 81–164 fire + 61–159 chaos damage, and 12% chaos resistance penetration. Gloom Bite (off-hand) adds +26% damage over time multiplier plus flat fire/cold/lightning damage, all of which pipes into poison scaling because Viper Strike of the Mamba's poison inherits from the weapon's full hit damage. Both weapons alternate per strike, so every hit gets one of the two DoT multipliers applied. The 6-link migrates into Doppelganger Guise: Viper Strike of the Mamba + Melee Physical Damage Support + Fortify + Swift Affliction + Added Chaos Damage + Deadly Ailments SupportFortify replaces Efficacy for the melee-range defensive buff, and Melee Physical Damage Support scales the physical portion that feeds poison.

Doppelganger Guise's Unhinge mechanic is the boss-phase pivot: the chest grants a Level 20 Unhinge skill that toggles Insane state for 54% more critical strike chance, and Sane state gives 34% less physical and chaos damage taken. The build sits Sane during trash and flips Insane on bosses for the crit burst. Despair is now self-cast via Alchemist's Mark + Battlemage's Cry on the gloves, and Autoexertion keeps the warcry running. Whirling Blades + Faster Attacks in the helmet replaces Flame Dash for true melee mobility. Tree picks up Intuition, Acuity, and Revenge of the Hunted for raw crit + evasion scaling, and drops pure poison notables that the rare daggers now duplicate.

Defensive layers

EHP doubles to 35.8k and suppress climbs to 87%. The Tides of Time belt is the defensive centerpiece — +314 armour/evasion, 100% increased life recovery from flasks, 25% increased flask effect, and passive charge regen on life/mana/utility flasks. Pathfinder's Nature's Adrenaline + Master Surgeon + Natural Remedies combined with the belt means Divine Life + Sulphur + Quicksilver + Sapphire (Taste of Hate) + Amethyst are essentially always active. Divine Flesh converts 50% of elemental damage taken to chaos, and 83% chaos resist (with 54% overcap) means the build takes elemental hits at roughly half their listed value. Ancestral Vision converts the 87% suppress into 43% elemental ailment avoidance. Petrified Blood + Arctic Armour + Flesh and Stone add layered damage mitigation. Life regen 5,880/s + ES regen 5,876/s via Replica Sorrow of the Divine's Eldritch Battery flask covers sustained combat.

What it feels like

Smoother and more deliberate than early mapping. Whirling Blades gives instant repositioning into pack centers, Unhinge proc from Doppelganger Guise triggers the kill-destruction explosion on clear, and Battlemage's Cry bursts Despair application across whole screens. Single-target is stutter-step: Whirling Blades in, apply 2-3 Viper Strike of the Mamba stacks, Whirling Blades out, watch the chaos damage over time pool melt the boss. Flask uptime is effectively permanent during sustained combat — Pathfinder's Master Surgeon refills flasks on crit, the belt regens them on timer, and Natural Remedies extends every utility flask's duration. Flask effect scaling turns the Quicksilver + Sapphire + Amethyst trio into permanent buffs for all combat windows.

Passive tree (125 points)
Keystones
Chaos Inoculation Ghost Dance
Ascendancy
Master Toxicist Nature's Reprisal Nature's Adrenaline Nature's Boon
Notables
From the ShadowsMaster ToxicistCharismaSwift VenomsWritten in BloodWhispers of DoomInstinctPrimal SpiritFatal ToxinsCareful ConservationistSoul ThiefNature's ReprisalWastingVoid BarrierBallistics

The desktop app shows this tier's full tree on an interactive canvas.

Aspirational L95–100


What to work on next
  1. Aspirational commits to the Pathfinder flask + aura stacking identity. The helmet swaps to Brood Visor (Blizzard Crown with -9% enemy chaos resist nearby), boots become The Tempest Rising Goliath Greaves (damaging ailments deal damage 25% faster), a Sublime Vision prismatic jewel locks the build into Purity of Lightning-only aura mode with 38% increased aura effect, and The Light of Meaning prismatic jewel adds +4% chaos resistance to radius passives. Progenesis replaces the utility Amethyst flask and a Raise Spectre + Animate Guardian minion package fills the gloves.
Signature items
The Supreme Truth
The Supreme Truth
Crystal Sceptre
Foulborn Lightning Coil
Foulborn Lightning Coil
Desert Brigandine
Ashes of the Stars
Ashes of the Stars
Onyx Amulet
Kalandra's Touch
Kalandra's Touch
Ring
The Tides of Time
The Tides of Time
Vanguard Belt
Main link
Viper Strike of the MambaViper Strike of the Mamba
+Unbound AilmentsUnbound Ailments
+Melee Physical DamageMelee Physical Damage
+Deadly AilmentsDeadly Ailments
+Elemental Damage with AttacksElemental Damage with Attacks
+Swift AfflictionSwift Affliction
DPS
24.74M
EHP
78.8k
Life
4.1k

Stats measured in Path of Building at level 100, from the ladder data this guide is built on. Ladder median (n=93): 18.00M DPS · 82.1k EHP.

Full stats
Fire res
-60%
Cold res
-60%
Lightning res
90%
Chaos res
85%
Block
20%
Spell block
0%
Spell suppression
100%
Phys reduction
28%
Life regen
4.5k/s
Crit chance
8.8%
Crit multi
150%
Speed
1.45/s
Str / Dex / Int
180 / 175 / 201
Full gear (34 items)
Skull Needle Skull Needle Weapon 1
Skull Needle
Skull Needle Weapon 1
Pneumatic Dagger

  • Quality does not increase Physical Damage
  • +0.1 metres to Weapon Range per 10% Quality
  • All Damage from Hits with This Weapon can Poison

  • +36% to Chaos Damage over Time Multiplier
  • Adds 82 to 180 Fire Damage
  • Adds 19 to 320 Lightning Damage
  • Can have up to 3 Crafted Modifiers (crafted)
  • +24 to Dexterity and Intelligence (crafted)
  • 14% increased Attack Speed (crafted)
  • Hits can't be Evaded (crafted)
Spirit Barb Spirit Barb Weapon 2
Spirit Barb
Spirit Barb Weapon 2
Pneumatic Dagger

  • Quality does not increase Physical Damage
  • +0.1 metres to Weapon Range per 10% Quality
  • All Damage from Hits with This Weapon can Poison

  • +37% to Chaos Damage over Time Multiplier
  • Adds 83 to 168 Fire Damage
  • Adds 18 to 308 Lightning Damage
  • Can have up to 3 Crafted Modifiers (crafted)
  • +20 to Dexterity and Intelligence (crafted)
  • 15% increased Attack Speed (crafted)
  • Hits can't be Evaded (crafted)
The Supreme Truth The Supreme Truth Weapon 1 Swap
The Supreme Truth
The Supreme Truth Weapon 1 Swap
Crystal Sceptre

  • 30% increased Elemental Damage

  • Attacks with this weapon inflict Hallowing Flame on Hit
  • +1 to Level of Socketed Gems
  • 60% increased Intelligence Requirement
  • 89% increased Physical Damage
  • 15% increased Attack Speed
  • 3% increased Experience gain
The Supreme Truth The Supreme Truth Weapon 2 Swap
The Supreme Truth
The Supreme Truth Weapon 2 Swap
Crystal Sceptre

  • 30% increased Elemental Damage

  • Attacks with this weapon inflict Hallowing Flame on Hit
  • +1 to Level of Socketed Gems
  • 60% increased Intelligence Requirement
  • 97% increased Physical Damage
  • 19% increased Attack Speed
  • 3% increased Experience gain
Vortex Star Vortex Star Helmet
Vortex Star
Vortex Star Helmet
Blizzard Crown

  • Adds 83 to 128 Cold Damage
  • Your Hits treat Cold Resistance as 10% higher than actual value

  • +39 to Intelligence
  • 73% increased Evasion and Energy Shield
  • +95 to maximum Life
  • +46% to Lightning Resistance
  • 10% of Physical Damage from Hits taken as Lightning Damage
  • Nearby Enemies have -9% to Chaos Resistance
Foulborn Lightning Coil Foulborn Lightning Coil Body Armour
Foulborn Lightning Coil
Foulborn Lightning Coil corrupted Body Armour
Desert Brigandine

  • +2 to Level of Socketed Duration Gems
  • 4% reduced Lightning Damage taken

  • Adds 1 to 23 Lightning Damage to Attacks
  • 107% increased Armour and Evasion
  • -60% to Lightning Resistance
  • 50% of Physical Damage from Hits taken as Lightning Damage
  • 50% of Chaos Damage taken as Lightning Damage
Death Caress Death Caress Gloves
Death Caress
Death Caress Gloves
Phantom Mitts

  • +7% chance to Suppress Spell Damage
  • Non-Vaal Strike Skills target 2 additional nearby Enemies

  • Has 1 Abyssal Socket
  • +14% chance to Suppress Spell Damage
  • +53 to Strength
  • +126 to maximum Life
  • +69 to maximum Mana
  • 14% increased Melee Damage (crafted)
  • +0.1 metres to Melee Strike Range (crafted)
Corruption Tread Corruption Tread Boots
Corruption Tread
Corruption Tread Boots
Phantom Boots

  • 20% chance to Avoid Elemental Ailments
  • 4% increased Action Speed

  • Has 1 Abyssal Socket
  • +14% chance to Suppress Spell Damage
  • +113 to maximum Life
  • 30% increased Movement Speed
  • 34% chance to Avoid Elemental Ailments
  • 71% increased Evasion and Energy Shield (crafted)
Ashes of the Stars Ashes of the Stars Amulet
Ashes of the Stars
Ashes of the Stars Amulet
Onyx Amulet

  • Allocates Whispers of Doom
  • +19 to all Attributes

  • 6% increased Experience Gain of Gems
  • +1 to Level of all Skill Gems
  • +30% to Quality of all Skill Gems
Havoc Grasp Havoc Grasp Ring 1
Havoc Grasp
Havoc Grasp Ring 1
Fugitive Ring

  • +2% to maximum Chaos Resistance
  • Cannot roll Modifiers of Non-Chaos Damage Types

  • +15% to Damage over Time Multiplier
  • Adds 19 to 26 Fire Damage
  • Adds 16 to 24 Lightning Damage
  • Adds 9 to 89 Lightning Damage to Attacks
  • +105 to maximum Life
  • +32% to Chaos Resistance
  • +25 to Strength and Intelligence (crafted)
Kalandra's Touch Kalandra's Touch Ring 2
Kalandra's Touch
Kalandra's Touch Ring 2
Ring

  • Reflects opposite Ring
The Tides of Time The Tides of Time Belt
The Tides of Time
The Tides of Time Belt
Vanguard Belt

  • +308 to Armour and Evasion Rating

  • 100% increased Life Recovery from Flasks
  • 100% increased Mana Recovery from Flasks
  • Flasks applied to you have 25% increased Effect
  • Life Flasks gain 3 Charges every 3 seconds
  • Utility Flasks gain 3 Charges every 3 seconds
Ancestral Vision Ancestral Vision Jewel
Ancestral Vision
Ancestral Vision Tree Jewel
Viridian Jewel

  • +5 to Dexterity
  • Modifiers to Chance to Suppress Spell Damage also apply to Chance to Avoid Elemental Ailments at 50% of their Value
Pandemonium Prism Pandemonium Prism Jewel
Pandemonium Prism
Pandemonium Prism Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: 2% increased Damage over Time
  • Added Small Passive Skills also grant: +5% to Lightning Resistance
  • 1 Added Passive Skill is Brewed for Potency
  • 1 Added Passive Skill is Low Tolerance
Behemoth Vessel Behemoth Vessel Jewel
Behemoth Vessel
Behemoth Vessel Tree Jewel
Cobalt Jewel

  • Damaging Ailments deal damage 6% faster
  • 5% increased maximum Life
  • +2% to maximum Lightning Resistance
  • 16% increased Damage with Poison
Forbidden Flame Forbidden Flame Jewel
Forbidden Flame
Forbidden Flame corrupted Tree Jewel
Crimson Jewel

  • Allocates Focal Point if you have the matching modifier on Forbidden Flesh
Damnation Solace Damnation Solace Jewel
Damnation Solace
Damnation Solace Tree Jewel
Cobalt Jewel

  • +6% to Chaos Damage over Time Multiplier
  • 5% increased maximum Life
  • 16% increased Damage with Poison
  • Damaging Ailments deal damage 6% faster
Watcher's Eye Watcher's Eye Jewel
Watcher's Eye
Watcher's Eye Tree Jewel
Prismatic Jewel

  • 5% increased maximum Energy Shield
  • 5% increased maximum Life
  • 6% increased maximum Mana
  • 20% of Fire and Cold Damage taken as Lightning Damage while affected by Purity of Lightning
  • Gain 15% of Physical Damage as Extra Fire Damage while affected by Anger
Gale Scar Gale Scar Jewel
Gale Scar
Gale Scar Tree Jewel
Medium Cluster Jewel

  • Adds 5 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +2 to All Attributes
  • Added Small Passive Skills also grant: +4 to Strength
  • 1 Added Passive Skill is Brewed for Potency
  • 1 Added Passive Skill is Low Tolerance
Voices Voices Jewel
Voices
Voices corrupted Tree Jewel
Large Cluster Jewel

  • Adds 3 Jewel Socket Passive Skills
  • Adds 3 Small Passive Skills which grant nothing
Pandemonium Hope Pandemonium Hope Jewel
Pandemonium Hope
Pandemonium Hope Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +3 to All Attributes
  • Added Small Passive Skills also grant: +4% to Lightning Resistance
  • 1 Added Passive Skill is Brewed for Potency
  • 1 Added Passive Skill is Low Tolerance
Glorious Vanity Glorious Vanity Jewel
Glorious Vanity
Glorious Vanity Tree Jewel
Timeless Jewel

  • Bathed in the blood of 7402 sacrificed in the name of Xibaqua
  • Passives in radius are Conquered by the Vaal
  • Historic
Fulgent Curio Fulgent Curio Jewel
Fulgent Curio
Fulgent Curio Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +3 to All Attributes
  • Added Small Passive Skills also grant: +5 to Strength
  • 1 Added Passive Skill is Brewed for Potency
  • 1 Added Passive Skill is Low Tolerance
Foe Vessel Foe Vessel Jewel
Foe Vessel
Foe Vessel Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +3 to All Attributes
  • Added Small Passive Skills also grant: +4% to Chaos Resistance
  • 1 Added Passive Skill is Brewed for Potency
  • 1 Added Passive Skill is Low Tolerance
Voices Voices Jewel
Voices
Voices corrupted Tree Jewel
Large Cluster Jewel

  • Adds 3 Jewel Socket Passive Skills
  • Adds 3 Small Passive Skills which grant nothing
Spirit Sliver Spirit Sliver Jewel
Spirit Sliver
Spirit Sliver Tree Jewel
Medium Cluster Jewel

  • Adds 4 Passive Skills
  • 1 Added Passive Skill is a Jewel Socket
  • Added Small Passive Skills grant: 12% increased Chaos Damage over Time

  • Added Small Passive Skills also grant: +4 to All Attributes
  • Added Small Passive Skills also grant: +4% to Chaos Resistance
  • 1 Added Passive Skill is Brewed for Potency
  • 1 Added Passive Skill is Low Tolerance
Whispering Sphere Whispering Sphere Jewel
Whispering Sphere
Whispering Sphere Tree Jewel
Murderous Eye Jewel

  • Adds 13 to 25 Cold Damage to Attacks
  • Adds 3 to 44 Lightning Damage to Attacks
  • 13 to 23 Added Cold Damage with Dagger Attacks
  • 9 to 14 Added Chaos Damage with Dagger Attacks
Forbidden Flesh Forbidden Flesh Jewel
Forbidden Flesh
Forbidden Flesh corrupted Tree Jewel
Cobalt Jewel

  • Allocates Focal Point if you have the matching modifier on Forbidden Flame
Sublime Vision Sublime Vision Jewel
Sublime Vision
Sublime Vision Tree Jewel
Prismatic Jewel

  • Auras from your Skills have 40% increased Effect on you
  • 30% of Fire and Cold Damage taken as Lightning Damage while affected by Purity of Lightning
  • Aura Skills other than Purity of Lightning are Disabled
Divine Life Flask
Divine Life Flask corrupted Flask 1

  • 66% increased Amount Recovered
  • 33% reduced Recovery rate
  • Grants Immunity to Bleeding for 6 seconds if used while Bleeding
  • Grants Immunity to Corrupted Blood for 6 seconds if used while affected by Corrupted Blood
Progenesis
Progenesis Flask 2
Amethyst Flask

  • 15% reduced Charges per use
  • 31% increased Duration
  • When Hit during effect, 25% of Life loss from Damage taken occurs over 4 seconds instead
Replica Sorrow of the Divine
Replica Sorrow of the Divine Flask 3
Sulphur Flask

  • Life Recovery from Flasks also applies to Energy Shield during Effect
  • 50% increased Duration
  • Eldritch Battery during Effect
Quicksilver Flask
Quicksilver Flask Flask 4

  • 26% reduced Duration
  • 25% increased effect
  • 65% reduced Effect of Curses on you during Effect
Topaz Flask
Topaz Flask Flask 5

  • 23% reduced Duration
  • 25% increased effect
  • 55% Chance to Avoid being Stunned during Effect
All gem links (7 groups)
Helmet 4-link
  • Battlemage's Cry Battlemage's Cry 20/20
  • Autoexertion Autoexertion 20/20
  • Alchemist's Mark Alchemist's Mark 21/23
  • Despair Despair 20/20
Weapon 1 3-link
  • Withering Step Withering Step 20/23
  • Automation Automation L20
  • Enhance Enhance 4/20
Body Armour 6-link Main link
  • Unbound Ailments Unbound Ailments 20/20
  • Melee Physical Damage Melee Physical Damage 20/20
  • Viper Strike of the Mamba Viper Strike of the Mamba 21/23
  • Deadly Ailments Deadly Ailments 20/20
  • Elemental Damage with Attacks Elemental Damage with Attacks 20/23
  • Swift Affliction Swift Affliction 20/20
Weapon 2 3-link
  • Brutality Brutality 20/23
  • Faster Attacks Faster Attacks L20
  • Whirling Blades Whirling Blades 21/20
Gloves 2-link
  • Cast when Damage Taken Cast when Damage Taken 20/20
  • Spell Totem Spell Totem L1
Gloves
  • Purity of Lightning Purity of Lightning 20/20
Boots 3-link
  • Arctic Armour Arctic Armour 20/23
  • Petrified Blood Petrified Blood 20/20
  • Awakened Enlighten Awakened Enlighten 4/20
How this stage plays (mechanics, defences)
Mechanics

The endgame dagger pair carries forward with Chimeric Slicer (main hand, Hits can't be Evaded implicit + 11% attack speed) and Gloom Sever (+28% chaos DoT multiplier). The 6-link refines to Viper Strike of the Mamba + Melee Physical Damage Support + Elemental Focus + Swift Affliction + Added Cold Damage + Deadly Ailments SupportElemental Focus replaces Added Chaos Damage because the elemental portion of hits scales poison more efficiently once Brood Visor's treat cold resistance as 10% higher + Brood Visor's 85–127 cold damage helm implicit stack with Gloom Sever's added cold.

The scaling stack at full power: Wither from Withering Step on the helm (no more totem needed — Pathfinder's movement speed + flask uptime makes Withering Step permanent), Despair via Mark On Hit + Alchemist's Mark + Enhance on the helm gives Lv22+ Despair for -44% chaos resistance, Brood Visor's -9% chaos resistance aura, and the weapon's 12% penetration together push enemies to effectively -65% chaos resistance — the chaos damage over time pool then ticks at double-plus value. Tree adds Master of the Arena, Expert Hunter, and Art of the Gladiator, and the full Glorious Vanity / Divine Flesh / Sublime Vision axis converts half of all elemental damage taken to chaos where 81% chaos resist absorbs it. Sheet 5.1M DPS understates boss damage by roughly 2x because Wither, Despair, and Brood Visor's resist reduction compound on top.

Defensive layers

EHP 60.3k, 95% suppress, +1 minimum frenzy charge from the rare Synaptic Ring, 12% physical damage reduction, and Progenesis turning a quarter of all hit damage into a 4-second DoT — the combination is the classic Pathfinder one-shot-proof profile. Divine Flesh + 81% chaos res means elemental hits are absorbed by chaos mitigation rather than stacking with element-specific caps. Petrified Blood + Arctic Armour + Progenesis layer over 4,534/s life regen for sustain. Doppelganger Guise's Sane state still gives 40% less physical and chaos damage taken during trash, and Insane state is toggled for the crit burst window on bosses. The Tempest Rising's "You and Enemies count as moving while affected by Elemental Ailments" + Stormshroud's "avoid being shocked applies to all ailments" + flask shock/chill immunity rolls hold the ailment layer together. Flask uptime is effectively permanent — Master Surgeon + The Tides of Time + Natural Remedies + Nature's Adrenaline is the strongest flask-sustain stack in the game.

What it feels like

Apex Pathfinder flow: flask-soaked, ailment-drenched, one-shot-resistant. Withering Step applies Wither stacks during movement itself — no setup required — and Whirling Blades chains through packs while the animated spectre and guardian (Doppelganger Guise's Unhinge + the minion package) hold frontline aggro. Pinnacle bosses fall to the Despair + Wither + Brood Visor resist-reduction stack combined with the -65% effective chaos resist ceiling and Progenesis's DoT conversion absorbing their biggest telegraphs. Flask uptime is permanent, crit is boosted by Watcher's Eye's 108% increased crit chance against consecrated ground while affected by Zealotry, and the frenzy charge from the Synaptic Ring gives baseline attack speed + damage even on single-target pulls. Viper Strike of the Mamba remains what it always was — a slow-striking dagger with a chaos damage over time afterbite — but the ailment-compounding identity is now a full-spectrum boss-deletion setup.

Passive tree (134 points)
Keystones
Divine Flesh (transformed from Elemental Equilibrium)
Ascendancy
Master Toxicist Nature's Reprisal Nature's Adrenaline Master Surgeon
Notables
Master ToxicistSwift VenomsMultishotThrill of BattleToxic StrikesThick SkinHerbalismBlood DrinkerExpert HunterFatal ToxinsMark the PreyMaster of the ArenaIntuitionNature's ReprisalField Medicine

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